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What does people say about Xenical?

These are some opinions collected from Usenet about the use of Xenical.

Xenical is the brand name for the drug Orlistat produced by Roche in Switzerland. Regarding the drug itself, it is a non-systemic (does not act on the central nervous system, as do fenflauramine, prozac, etc.) preventative obesity treatment which works by "blocking" the absorption of about 30% of the fat in the food you eat. Its action is in the digestive system (lypase, I think, but can't recall for sure right now) and it is not extensively absorbed into the body as many other diet drugs are, so it is though to be relatively safe.

This is not, however, (in my humble opinion) a license to binge on high fat foods; 1) since it can only eliminate a certain amount of digested fat, and 2) eating too much fat while on this drug has been shown to cause side effects which will be unpleasant and probably unhealthy (such as serious diahrrea, nasuea, etc.). Also, common sense suggests that one does not want to increase one's unhealthy eating habits just because of this drug -- you don't want to cancel out the positive effects of Xenical by overeating, and you never can tell if a drug will later be found to have serious consequences (look at PhenFen and Redux, for example) and removed from the market. Then what would you do with all those indulgent, Xenical supported habits?!

Be aware that those persons taking Xenical must be sure to supplement their vitamin/mineral supply with a good over the counter multi vitamin or something, since one result of fat absorption-hindering will be a substantial loss of much needed vitamins. The manufacturer does mention some other minor and seemingly low-threat side effects which I cannot recall off hand, but if you search on Yahoo/Alta Vista for Xenical or Orlistat, you should be able to locate the pharmacological details. Good luck, and let me know if I can be of further assistance.


"Any opinions on xenical?"

Make sure you are near a lavatory at all times. 8-)

Seriously, have you read about the side effects?

It seems to me to be a very good drug, since it is non-systemic. As long as one does not mind "flatulence with discharge".


Xenical is a medicine, from Roche Pharmaceuticals, that targets the absorption of fat in your body rather than suppressing your appetite. Dietary fats are large molecules which need to be broken down by enzymes, called lipases, before they can be absorbed into the body. When taken with a meal, Xenical alters the activity of these enzymes and allows about one third of the fat to pass through the gut undigested. However if you still maintain a diet high in fat, yow will suffer from diarrhea, as the unabsorbed fat passes through your system.


Yes & i can say that i have great success; u must realise it is a slow method but i feel in the long term will be the best. I keep my fat below 40 actually as lo as i can get, as well i walk for at least 45 mins 1 - 2 a day.


I took it for 3 months and lost 30 lbs. You'll have the runs and some urgent once. This can be amplified by increasing your fat intake.


"Has anyone been using this drug long term? I have been on it for a year now. Saw some weight loss at the beginning and my doctor I suggested I stay on it for maintenance. I am concerned about staying on this due to the warnings about losing necessary vitamins and minerals as a side effect. Who needs to take something for their health and then get sick as a result. Any thoughts?"

The FDA have recommended that Xenical users take a vitamin supplement that contains vitamins D, E, K, and beta-carotene, however we are not aware of any studies that have shown Xenical will lower the levels of these vitamins in the body.

This recommendation is based on the theory that these Vitamins are all fat soluble, and as more fat is excreted when you take Xenical, then more of these Vitamins will be excreted.

If you are eating a well balance diet, as you should be while taking Xenical, I would not be at all concerned.


I take a single xenical (when I remember) each night 1 hour before dinner. I have been doing this for 4 weeks. My dinner is usually none-too fatty but it is the one time a day I allow myself processed foods and I use the xenical to offset any hidden fats. And yes, do take a multivite whenever possible. At first I found my body suffered from flatulence, greasy discharge, and a rather "immediate need" to use the bathroom that couldn't wait. However, since my foods are altogether low in fat and small in quantitiy, as well as only taking 1 xenical a day, those symptoms have passed.


I like the Xenical. I don't know if I have lost any weight on it but that's more because of a lowfat high exercise diet. Xenical is like anything else. It isn't a miracle drug. If you pop a pill and then eat a dozen deep fat fried jalepeno and chedder poppers and drink a couple fo beers, not only are you in for some big discomfort but you are definitely not going to lose weight.

For myself it's an insurance policy and nothing else. That way, if I do indulge, I'll gain less. Also, how are you taking it? I have found that if I take it 30-45 minutes before a greasy meal it helps a lot more than if I take it closer, during, or after the meal.


My father was on it. He lost about 60 lbs or so, so far. (my dad is about 80 lbs over weight) It prevents your body from absorbing fat. but one word of advice that both my father in law and dad told me is that if you eat food too high in fat content, it sometimes causes the runs, or the inability to control your bowel movements, or oily discharge from your tuchus. but from what I hear from my dad, if you watch the fat content, then its fine.


I must be quite fortunate then as I've been on it a little while with no side effects whatsoever (I'm very glad to say), my hubby is on it too and he's had no side effects either. Do they come on straight away or take a while to appear? As for the cost I know its expensive, but being from the UK all it costs us is the NHS prescription price which is £6 each (around $10 i think) for a months supply...so again I'm even more fortunate.


I've lost 54ibs already but i've hit the plato and need a bit off a push have any off you tried it and what results have you had?


I've been surprised that I haven't had trouble with xenical. The first week I had frequent (but no diarrhea) episodes. The after that, no problem. The Meridia can be constipating, so maybe the mix of the two works well. I take the xenical a few times a week, not every day.


I've been on xenical 3 months and lost around 24 lbs so far. I find that it has no side effects at all as long as I eat very low fat. If I ate what I would consider an average meal, for instance a couple of sausages (even the low fat variety), mash and baked beans, then I would have problems. And these are not the nicest side effects in the world to get. Basically the tablets get rid of the fat they stop you absorbing by sending it out of the opposite end to your mouth :0) And usually with no warning...lol. And this is the weird part.....the fat it sends out is bright orange. But, with a low fat diet there 'shouldnt' be any problems.


Ok, my take on Xenical: When I was on it, I was afraid to eat the way I wanted to for fear of the side effects. With Xenical, if you limit your fat intake to 30%, there are no side effects. It seems to defeat the purpose to take Xenical and limit your fat intake to 30%. Why waste money on Xenical if you limit your fat to 30% anyway? My question is... If you eat 30% or less fat per meal, and Xenical is working as it should, does that mean that 30% fat is being bypassed somehow? Like, using Xenical and leating 30% fat or less would be the equivalent of a fat-free diet -??? Since Xenical seems to work *best* when it's doing the shit through a goose thing and you're over the 30% fat limit to get those effects, staying at or under the 30% fat limit seems the sensible choice, with or without Xenical. It seemed to me that unless I was going to eat over 30% fat, that the Xenical was gilding the lily, so to speak.


I guess the idea is, limit your fat intake to 30% because Xenical gets rid of 30%, so yes, in essence you end up with a fat-free diet. I'm sure some types of fats may be retained, or you'd dry up like never before. I've been limiting myself and haven't had the side effects since the first day I took it.


I live in the UK and was one of the first patients to recieve Xenical free from the National Health Service. I had no side affects for about 10 days and then I just got a change in bowl habbits, but as long as you eat a healthy diet this is nothing serious. I v'e been on it for a year now and I have lost 56 pounds now I wiegh 130kg and I'm still losing. THe only thing is it is recommended that you stop taking Xenical after 2 years or it could cause some damage.


Well, as someone who is taking xenical with such success, there are several things which I would like to point out.

Xenical is *not* a quick fix. You can't eat like a pig and then expect to lose weight. If you are serious about losing weight, you need to do your part as well. Which means low-fat, high fiber, healthy diet, drink your water and make sure to get plenty of exercise.

As for the side effects, the people who get the bad side effects are ones who think they can eat like a pig because they've got this magic pill. Xenical prevents your body from absorbing 30% of the fat you consume in a meal. That fat has to go somewhere, so it just passes through you. So, if you have a nice healthy dinner with about 15-20 grams of fat, you *won't* have the gross side effects. But if you chow down on a Big Mac and fries or something similar with a high fat content, you are going to have the side effect. That is one of the benefits of Xenical IMO. If you have a big fatty meal, you know that you will suffer the reprecussions in a few hours, so it makes you think twice. My doctor and I both felt that was a benefit.

Also, I started taking it after being on Weight Wathcers for 4 months. During that time, I'd followed plan very stictly, drank my water, ran 12-16 miles a week, swam, took yoga and lifted weights. I was losing weight, but very slowly. My personal trainer felt that I should talk to my doctor, since I was doing everything right, but the weight just didn't want to budge. So my doctor ran the slew of thyroid tests, and everything came back normal, thankfully. Then he suggested Xenical. At WW I had been losing about a pound a week, with my first week of Xenical, I've lost 4.5. I am going to continue with WW, as it is a sound program to help you learn a new way of life- which everyone must adopt they are serious about losing and KEEPING the weight off.

The only side effects of Xenical are the loose, oily stools, which you can control by following the plan they set forth correctly. I would caution people against Meridia, there is a reason that it is considered a controlled substance, and why they won't let people take it for than 2 years. When you are messing with your brain chemistry, watch out.

So for those of you who said you need to change your way of life, I agree heartily. But Xenical is something which is helping me, and many others, be more successful at weight loss.

Do you have experience using Xenical? Tell me and I'll post it here.

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