The Mystery Journey~Multiple Sclerosis

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~What Is Multiple Sclerosis?~

Illustration of a nerve cell

What is multiple sclerosis?

Multiple sclerosis (MS) is a chronic neurological disease that involves the central nervous system specifically the brain, spinal cord, and optic nerves. MS can cause problems with muscle control and strength, vision, balance, sensation, and mental functions.
The brain, spinal cord, and optic nerves are connected to one another by nerves and nerve fibers. A protein coating called myelin surrounds and protects the nerve fibers. When myelin becomes inflamed or is destroyedthis is called demyelinationthe result is an interruption in the normal flow of nerve impulses through the central nervous system. The process of demyelination and subsequent disruption of nerve impulse flow is the disease known as MS.
Injured tissue called lesions or plaques form in areas of demyelination. In many cases, the cells (oligodendrocytes) that create myelin are destroyed, as are the nerve fibers (axons). The body is then not able to heal the myelin or nerve fibers, which further contributes to disability.
Generally, MS follows one of four courses, which are called:1
  • Relapsing-remitting, where symptoms may fade and then recur at random for many years.
  • Secondary progressive, which initially follows a relapsing-remitting course. Later on, it becomes steadily progressive.
  • Primary progressive, where the disease is progressive from the start.
  • Progressive relapsing, where steady deterioration of nerve function begins when symptoms first appear. Symptoms appear and disappear, but nerve damage continues.

Learn More About MS & Support~

~What MS Is & Possible Symptoms~

 

What is Multiple Sclerosis

Multiple sclerosis is a chronic, often disabling disease of the central nervous system. Symptoms may be mild such as numbness in the limbs or severe -- paralysis or loss of vision.

Most people with MS are diagnosed between the ages of 20 and 40 but the unpredictable physical and emotional effects can be lifelong. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are giving hope to those affected by the disease.

Symptoms

The symptoms of MS are highly variable, depending on the areas of the central nervous system that have been affected. Not only do the symptoms vary from one person to another, but from day to day for any given individual. 

Symptoms

Additional symptoms that may be associated with this disease:

Note: Symptoms may vary with each attack. They may last days to months, then reduce or disappear, then recur periodically. Fever can trigger or worsen attacks, as can hot baths, sun exposure, and stress.


Signs and tests

Symptoms of MS may mimic many other neurologic disorders. A history of at least two attacks separated by a period of reduced or no symptoms may indicate the pattern of attack/remission seen in MS. If there are observable decreases in any functions of the central nervous system (such as abnormal reflexes), the diagnosis of MS may be suspected.

Examination by the health care provider may show focal neurologic deficits (localized decreases in function). This may include decreased or abnormal sensation, decreased ability to move a part of the body, speech or vision changes, or other loss of neurologic functions. The type of
neurologic deficit may indicate, to some extent, the location of the damage to the nerves.

Eye examination may show abnormal pupil responses, changes in the visual fields or eye movements, nystagmus (rapid eye movements) triggered by movement of the eye, decreased visual acuity, or abnormal findings on a fundoscopy (an examination of the internal structures of the eye).

Tests that indicate or confirm multiple sclerosis include:

 

 

Causes of MS

Many people with MS ask if their disease is caused by a virus or other infectious agent. Much research has focused on trying to answer this question.

 

It is tempting to speculate on a viral cause for MS because viruses are known to cause demyelinating disease in animals and humans. Demyelination (destruction of myelin—the fatty sheath the surrounds and insulates nerve fibers in the central nervous system), causes nerve impulses to be slowed or halted and produces the symptoms of MS.

 

Data from epidemiological studies—those that analyze variations in geographical, socioeconomic, genetic, and other factors—suggest that exposure to an infectious agent may be involved in causing MS. Some viruses are known to have a long latency period between time of infection and appearance of clinical symptoms, as is thought to be the case in multiple sclerosis.

 

No Definitive Evidence to Link Any One Virus to MS

Although many different viruses have been suggested to cause MS, there has not yet been definitive evidence linking any one virus to the autoimmune reaction that is believed to be the process responsible for the demyelination seen in MS.  At one time or another, canine distemper virus, measles virus, herpes virus (HHV-6), rubella (or German measles) virus, HTLV-1 virus, and others have been reported to be associated with MS. With the possible exception of HHV-6, later studies have not substantiated these reports, and there is no proof that any of them causes MS.

 

Increased antibodies to many different viruses have been found in

the sera and cerebrospinal fluid of people with MS. This may not necessarily represent disease-causing infection by these viruses. It is more is likely to be the result of non-specific immune activation. The role of a virus as a causative or triggering agent of MS remains speculative.

 

MS is not Contagious

Currently, there is no evidence at all to suggest that MS is infectious or contagious. The role of a virus or viruses, if there is one, affects only people with a genetic predisposition to develop MS.

Source of information: National MS Society

Genetics of multiple sclerosis: linkage and association studies

Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system caused by an interplay of environmental and genetic factors. The only genetic region that has been clearly demonstrated by linkage and association studies to contribute to MS genetic susceptibility is the human leukocyte antigen (HLA) system. The majority of HLA population studies in MS have focused on Caucasians of Northern European descent, where the predisposition to disease has been consistently associated with the class II DRB1*1501-DQA1*0102-DQB1*0602 haplotype. A positive association with DR4 was detected in Sardinians and in other Mediterranean populations. Moreover DR1, DR7, DR11 have been found to be protective in several populations. Systematic searches aimed at identifying non-HLA susceptibility genes were undertaken in several populations by means of linkage studies with microsatellite markers distributed across the whole genome. The conclusion of these studies was that there is no major MS locus, and genetic susceptibility to the disease is most likely explained by the presence of different genes each conferring a small contribution to the overall familial aggregation. The involvement of several candidate genes was tested by association studies, utilising either a population-based (case control) or a family-based (transmission disequilibrium test) approach. Candidate genes were selected mainly on the basis of their involvement in the autoimmune pathogenesis and include immunorelevant molecules such as cytokines, cytokine receptors, immunoglobulin, T cell receptor subunits and myelin antigens. With the notable exception of HLA, association studies met only modest success. This failure may result from the small size of the tested samples and the small number of markers considered for each gene. New tools for large scale screening are needed to identify genetic determinants with a low phenotypic effect. Large collaborative studies are planned to screen several thousands of patients with MS with several thousands of genetic markers. The tests are increasingly based on the DNA pooling procedure.

note:  www.friendswithms.com 

What is Multiple Sclerosis?

Multiple Sclerosis

Multiple sclerosis (MS) is a chronic, long-term condition that affects the central nervous system, which includes the brain and spinal cord. MS is an autoimmune disease, which means that the body's immune system mistakenly attacks itself, targeting the cells, tissues, and organs.

Multiple sclerosis is a part of the family of autoimmune diseases that includes:

  • Rheumatoid arthritis
  • Psoriasis
  • Type 1 diabetes
  • Lupus
  • Crohn's disease

Scientists now believe that multiple sclerosis results from an abnormal response to an infection or an environmental factor. Numerous studies show that genetics may play a role in the development of multiple sclerosis, but are not the sole cause of the disease.

Multiple sclerosis affects over 400,000 people in the US, and may affect 2.4 million people worldwide.

What causes multiple sclerosis?

Despite a great deal of research, the exact cause of multiple sclerosis has not yet been discovered. However, evidence suggests that environmental factors and infectious agents such as viruses and bacteria have been proposed as triggers.

Although there is currently no way to decrease a person’s risk of developing multiple sclerosis, we know that risk is slightly higher if a parent or sibling has it.

How is Multiple Sclerosis Diagnosed?

No one test can identify or rule out multiple sclerosis. Your healthcare provider may want you to have several tests or procedures. Most of them are painless.

A multiple sclerosis diagnosis usually begins with a complete neurological examination and a discussion of your full medical history with your healthcare provider. He or she will need an overall view of your health, including your symptoms and when they started. However, it may still be difficult, if not impossible, to confirm the presence of multiple sclerosis without using certain procedures.

Many healthcare providers use magnetic resonance imaging (MRI) to help diagnose MS at an early stage by providing a detailed picture of the brain. Early diagnosis means that treatment can begin right away, rather than waiting for continued relapses to confirm diagnosis.

Other tests for multiple sclerosis may include:

  • Evoked potential tests, which measure how a person’s nervous system responds to certain stimulation
  • Spinal tap, which checks spinal fluid for signs of multiple sclerosis

Your healthcare provider will determine which test is best suited for the type of symptoms that you have.

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Multiple Sclerosis Symptoms

Multiple sclerosis (MS) can cause a wide range of symptomsmultiple sclerosis symptoms. Some problems occur often, and some are seldom seen. The course of illness is different for each person. Even when there are no symptoms, there is progression of damage to the central nervous system over time. That's why it is important to stay on your multiple sclerosis treatment. Common multiple sclerosis symptoms are:

Optic Neuritis

This multiple sclerosis symptomsis an inflammation of the optic nerve, the nerve that controls the eye. Over a period of days, you may develop blurred vision. Sometimes you may feel pain behind your eye, which increases when you turn your eye. After initial symptoms, there is gradual improvement, sometimes after several weeks. But recovery is not always complete. During periods of stress, fatigue or fever, the blurred vision in the eye may return. This does not necessarily mean that the multiple sclerosis is active again. Rather, it may be the result of permanent disability that has accumulated over time.

Loss of Muscle Strength in Arms and Legs

The nervous system contains large numbers of nerve fibers that control movement - what we call motor function. Often, multiple sclerosis is active on the nerve fibers that control muscle movement. Many people with multiple sclerosismultiple sclerosis symptoms lose muscular strength in the arms and legs as the disease progresses. The loss can range from reduced dexterity (the fingers no longer work so well) to paralysis of an arm or leg. Loss of muscular strength occurs not only in the form of relapses (temporary attacks) but also as a gradual (progressive) process without recovery. Gradual loss of strength occurs more frequently in the legs than in the arms. Depending on the severity, you may need to rely on a cane, crutches, or even a wheelchair to get around.

Change in Sense of Touch

The vast nervous system includes many sensory nerve fibers dedicated to helping you be aware of your environment. They provide the sense of touch in your fingers, and your ability to feel cold or heat on all parts of your body. When these fibers are damaged through multiple sclerosis, your sense of touch may be replaced by feelings of numbness or tinglingmultiple sclerosis symptoms. Parts of your body may feel burning or cold, even though there is no heat or chill present. Symptoms multiple sclerosis symptomscan be temporary (relapses) or more progressive, and can occur in various parts of the body. This could be just one part of an arm or leg, in the whole lower half of the body, say below the navel, or in a collection of numb patches occurring randomly all over the body.

Pain

Multiple sclerosis can be accompanied by various kinds of painmultiple sclerosis symptoms. Damage to the sensory tracts in the spinal cord can result in burning pain in the arms and legs. Multiple sclerosis can often result in damage to the nerves of the face, a painful condition known as "trigeminal neuralgia." If multiple sclerosis has impaired your ability to walk, the extra strain in the muscles of your back and legs can become painful. Multiple sclerosis can also cause extra tension in the muscles of your arms and legs: this is known as "spasticity" and can also be painful.

Bladder/Bowel Problems

Many people with multiple sclerosismultiple sclerosis symptoms will develop trouble controlling the urge to urinate or will be unable to completely empty the bladder. Less frequently, they will also experience problems with bowel control. As multiple sclerosis progresses and you develop a more sedentary lifestyle, you may also be troubled with constipation.

Sexual Dysfunction

Having multiple sclerosis can lead to problems related to sexual activitymultiple sclerosis symptoms, especially if your bladder or bowels are already affected. Men with multiple sclerosis can find it difficult to achieve or maintain an erection. In women, multiple sclerosis often causes a loss of sexual sensitivity, pain during intercourse, an inability to achieve an orgasm, or a reduction in naturally produced lubrication.

Balance/Coordination Problems

The part of the brain known as the cerebellum controls and corrects all our movements. Damage from MS can result in poor balance or coordination. You may, for instance, have difficulty grasping small objects, writing clearly, or keeping a steady hand. When walking across a room, you may find yourself losing your balance, as if you were intoxicated. Like most other multiple sclerosis symptoms, these problems can be temporary (during a relapse), or they can be a permanent result of the progression of multiple sclerosis.

Fatigue

Many people with multiple sclerosis experience fatigue or tirednessmultiple sclerosis symptoms. But since fatigue can be a sign of so many other diseases, too, it is not often immediately identified as being caused by multiple sclerosis. Fatigue occurs in both relapsing multiple sclerosis and in the more progressive types of the disease. It can often last for a few months during which time your energy is used up every day with just a little exertion.

Changes in Cognitive Function

At some point in the course of your illness with multiple sclerosis, you may notice changes in cognitive function, such as your memory and speed of thinking. You may also have difficulty concentrating, making it hard for you to focus your attention. In some patients these multiple sclerosis symptomssymptoms can occur early in the disease; in others, they can come later.

Mood Changes

Many people with multiple sclerosis experience periods of depression. Sometimes it is linked directly to physical changes in the brain caused by multiple sclerosis. Understandably, it may also be an emotional reaction to having the illness and learning to cope with the symptomsmultiple sclerosis symptoms and the challenges they represent. If you are experiencing feelings or symptoms multiple sclerosis symptomsof depression or hopelessness, discuss them with your doctor because treatment for depression is available.

Multiple sclerosis is a diagnosis that can be made only after every other possible explanation of the signs and symptoms has been ruled out.

There are a number of medicines available to help manage multiple sclerosis. They fall into two basic categories:

  • Medicines that treat multiple sclerosis symptoms
  • Medicines that treat the underlying disease

Talk with your healthcare provider about the best treatment option for you.

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