~SOLARAY is a great Brand of DL-Phenylalanine. It can be bought at most health food stores, sometimes having to be special ordered.~
DL-PHENYLALANINE
DL-Phenylalanine (DLPA) is an essential amino acid, meaning the body produces this from the diet. DLPA is a mirror image of the amino acid phenylalanine, it shares a lot of the same benefits as phenylalanine, but in the DL form, its properties for controlling pain naturally are truly amazing.
It has been shown by several researchers to be far more effective in the control of pain than almost any other analgesic on the market. The only problem from the analgesic stand-point is that it requires anywhere from seven to fourteen days to be effective for relieving most pain. It is not a fast acting pain killer and should not be expected to produce results for some short duration pains that may last only a few hours, headache or slight sprain, for example.
However once pain relief effects are established, they can last for extremely long periods after discontinuing, since they stayed stored within the body and are called upon when needed. Another short term analgesic (such as White Willow), with anti-inflammatory properties must be taken in conjunction with DLPA in order to alleviate the short term pain, giving DLPA time to activate the natural pain-killing systems within the body. The two such elements, a short- term analgesic and DLPA, taken in combination biologically compliment each other and become one of the most effective OTC weapons available to fight rheumatoid and osteo-arthritis, migraine, menstrual cramps, lower back and joint pain, postoperative pain, and neuralgia.
It has been discovered that the human brain responds to pain by producing and activating morphine-like hormones, called endorphins. These hormones constitute the active portion of a naturally built-in pain relief system. DLPA operates to protect this pain relief system from certain destructive enzymes (carboxypeptidase A and enkephalinase enzymes). DLPA consequently allows the pain relief system to exert its powerful pain-relieving influence for an extended period of time.
DLPA has other features such as, anti-depressant, weight control, stress, appetite suppressant, and mood elevator.
In conclusion DLPA is a very effective painkiller, it is safe for long term use with no know toxicity levels, so therefore toxic overdose is impossible. It is important to know that DLPA does not cure the disease, which causes the pain, you must continue your other therapies.
The dosage recommended: two capsules of 500 mg, three times per day, thirty to forty minutes before meals for a period of seven days. Thereafter, a maintenance dosage of two capsules a day should be taken. DLPA is not recommended for use by pregnant or lactating women or phenylkertonerics (PKU). Those suffering from high blood pressure should take their tablets immediately after meals.
In the author's clinical experience, concurrent treatment with DL-phenylalanine (DLPA) often appears to potentiate pain relief and also ease depression in patients receiving opiates for chronic non-malignant pain. An analysis of this phenomenon suggests that it may be mediated, at least in part, by up-regulation of the 'endogenous analgesia system' (EAS), a neural pathway that projects caudally from medullary nuclei to the dorsal horn of the spinal column; when stimulated by chronic pain or therapeutic measures such as opiates or acupuncture, the EAS suppresses activation of second-order pain-receptive neurons in the dorsal horn, and thereby alleviates pain. Since serotonin and enkephalins are key neurotransmitters in the EAS, it is reasonable to predict that measures which promote serotonin activity (such as 5-hydroxytryptophan and serotonin-reuptake inhibitors) as well as enkephalin activity (such as D-phenylalanine, an enkephalinase inhibitor) should potentiate EAS-mediated analgesia - a view consistent with much previous medical research. Comprehensive support of the EAS with well-tolerated nutrients and pharmaceuticals may amplify the analgesic efficacy of chronic opiate therapy, while enabling dosage reductions that minimize opiate side-effects. Analogously, this approach may complement the efficacy of acupuncture and other analgesic measures that activate the EAS.D-phenylalanine is unique among amino acids because the D-form (normally not found in life) has biological activity, that is different from its L-stereoisomer. D-phenylalanine has been found to function as a pain reliever. DL-phenylalanine is a 50/50 mixture of the two stereoisomers.*****Dosage and use:
- Suggested dose is 500 to 1000 mg in the morning or afternoon.
- More may be necessary for depression or pain.
- These products are most effectively utilized when taken on an empty stomach mixed with juice or water.
- Adequate cofactors (vitamins B6 and C) should also be taken if not included with the product.
Caution:
Cancer patients should avoid taking L-phenylalanine and L-Tyrosine. Certain cancers, such as melanoma, depend on these amino acids to fuel their growth. Supplemental use of L-phenylalanine and L-Tyrosine may raise or normalize blood pressure. Insomnia may occur from overstimulation if taken too close to bedtime............ ......... ......... ......... ......... ........ ..........
DLPA is simple shorthand for DL-Phenylanlanine To the best of my limited knowledge, DLPA DL-Phenylanlanine is like saying “Rio Grande River”.
L-phenylalanine (LPA) serves as a building block for the various proteins that are produced in the body. LPA can be converted to L-tyrosine (another amino acid) and subsequently to L-dopa, norepinephrine, and epinephrine. LPA can also be converted (through a separate pathway) to phenylethylamine, a substance that occurs naturally in the brain and appears to elevate mood.
D-phenylalanine (DPA) is not normally found in the body and cannot be converted to L-tyrosine, L-dopa, or norepinephrine. As a result, DPA is converted primarily to phenylethylamine (the potential mood elevator). DPA also appears to influence certain chemicals in the brain that relate to pain sensation.
DLPA is a mixture of LPA and its mirror image DPA. DLPA (or the D- or L-form alone) has been used to treat depression among other things.
Regards,
Bruce Guilmette, Ph.D.
Survive Cancer Foundation, Inc.
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Guidelines for Use
As with other amino acid supplements, it's best to take DLPA on an
empty stomach with water or juice about an hour before meals. High-
protein foods, in particular, can interfere with proper absorption.
Store in a cool, dry place, such as a closet shelf, away from heat,
light, and moisture. (Avoid the humid bathroom medicine cabinet.)
General Interaction
Because DLPA exerts its effects through the central nervous system,
avoid taking it with prescription antidepressants or stimulants,
unless specifically instructed to do so by your doctor.
Some research indicates that DLPA can exacerbate facial tics and
other symptoms of tardive dyskinesia, a troubling movement disorder
caused by long-term use of antipsychotic medicines. Stop taking DLPA
and consult your doctor if you are concerned about a reaction you are
having.
As with other amino acids, DLPA may interfere with the effects of
levodopa, a drug commonly used to treat Parkinson's disease. Don't
combine the two.
Possible Side Effects
At recommended doses, DLPA occasionally causes mild side effects,
such as heartburn, nausea, or headaches. At excessive doses (more
than 1,500 mg a day), it can cause numbness, tingling, or other signs
of nerve damage.
DLPA may have the unwanted effect of raising blood pressure, although
the D, L combination form is less likely to do so than supplements
containing only the "L" form of the amino acid.
Cautions
Use DLPA under the supervision of a doctor familiar with its use.
When taken in high doses--greater than 1,500 mg a day--over prolonged
periods of time, nerve damage may develop. Lower doses appear to be
safe.
If you have high blood pressure or are prone to anxiety or panic
attacks, DLPA could seriously aggravate your condition. Let your
doctor know if signs or symptoms worsen while taking DLPA.
Pregnant women should not take DLPA, since it has not been well
studied in this group. If you are planning to become pregnant, let
your doctor know.
If you have been diagnosed with malignant melanoma, a potentially
deadly form of skin cancer, some doctors caution against taking DLPA.
There has been some concern that phenylalanine could stimulate the
cancer cells, although the connection, if any, remains unclear.
Do not take DLPA if you have phenylketonuria (PKU), a rare, inherited
metabolism disorder. People with this disease lack an enzyme that
converts phenylalanine to tyrosine and must follow very strict
dietary guidelines to prevent toxic damage to the nervous system.
Even though DLPA is a potent depression fighter, it should not be
used for this condition at the expense of other health-promoting
strategies, such as exercise and a healthy diet.
Ailments Dosage
Chronic Pain Up to 1,500 mg a day in 2 or 3 divided doses between
meals.Note Above: Dr. Bihari's Recommendation for MS Patients~Highlighted in Blue
DL-PHENYLALANINE
DL-Phenylalanine (DLPA) is an essential amino acid, meaning the body produces this from the diet. DLPA is a mirror image of the amino acid phenylalanine, it shares a lot of the same benefits as phenylalanine, but in the DL form, its properties for controlling pain naturally are truly amazing.
It has been shown by several researchers to be far more effective in the control of pain than almost any other analgesic on the market. The only problem from the analgesic stand-point is that it requires anywhere from seven to fourteen days to be effective for relieving most pain. It is not a fast acting pain killer and should not be expected to produce results for some short duration pains that may last only a few hours, headache or slight sprain, for example.
However once pain relief effects are established, they can last for extremely long periods after discontinuing, since they stayed stored within the body and are called upon when needed. Another short term analgesic (such as White Willow), with anti-inflammatory properties must be taken in conjunction with DLPA in order to alleviate the short term pain, giving DLPA time to activate the natural pain-killing systems within the body. The two such elements, a short- term analgesic and DLPA, taken in combination biologically compliment each other and become one of the most effective OTC weapons available to fight rheumatoid and osteo-arthritis, migraine, menstrual cramps, lower back and joint pain, postoperative pain, and neuralgia.
It has been discovered that the human brain responds to pain by producing and activating morphine-like hormones, called endorphins. These hormones constitute the active portion of a naturally built-in pain relief system. DLPA operates to protect this pain relief system from certain destructive enzymes (carboxypeptidase A and enkephalinase enzymes). DLPA consequently allows the pain relief system to exert its powerful pain-relieving influence for an extended period of time.
DLPA has other features such as, anti-depressant, weight control, stress, appetite suppressant, and mood elevator.
In conclusion DLPA is a very effective painkiller, it is safe for long term use with no know toxicity levels, so therefore toxic overdose is impossible. It is important to know that DLPA does not cure the disease, which causes the pain, you must continue your other therapies.
The dosage recommended: two capsules of 500 mg, three times per day, thirty to forty minutes before meals for a period of seven days. Thereafter, a maintenance dosage of two capsules a day should be taken. DLPA is not recommended for use by pregnant or lactating women or phenylkertonerics (PKU). Those suffering from high blood pressure should take their tablets immediately after meals.
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