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Metronidazole (Flagyl) may have a similar effect if taken with alcohol.
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Smolinske SC, Dietary supplement-drug interactions , Journal of the America Medical Woman's Association 1999; 54(4): 191-192, 195.
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When given by itself, levodopa is metabolized in the peripheral tissues outside the brain, which decreases the effectiveness of the drug and increases the risk of adverse effects.
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Formal pharmacokinetic studies on drug combinations are limited.
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