Cancer Molecular Biology Lab

Ege University, Engineering Faculty,
Dept. of Bioengineering
EBILTEM Hall,
35100, Bornova, Izmir, TURKEY
mobile: +90 538 3087613
Home: +90 232 3396163
work : +90 3884955 ext 2582x30

We are currently working on about molecular biology of prostate cancer, in terms of DNA damage repair, H2AX phosphorylation and the rate of foci formation as a response to DNA damage. We are interested in ATM, ATR, CHK1, CHK2 p53 (Ser15, Ser16,Ser20) phosphorylations, temporal and sequestral pattern of physical associations of DSB repair complex’ during the damage repair response and the influences of NKX3.1 on these  by the topoisomerase inhibitors mediated damage and repair processes.

We are also isolating and characterizing putative anti-cancer compounds extracted from endemic Alkanna sp. in Turkey.   

1.       HABOLD C., GALI-MUHTASIB H., KORKMAZ K.S., HARTIG R., ROESSNER A., SCHNEIDER-STOCK R. Acetylation-dependent upregulation of p21^WAF1 expression after H₂O₂-associated DNA-damage in colorectal cancer cells. Journal of Cellular and Molecular Medicine. March-April 12(2):607-21,2008.

2.       PEKIN, G., GANZERA, M., SENOL, S., BEDIR, E., KORKMAZ, K. S., STUPPNER, H. Determination of naphthazarin derivatives in endemic Turkish Alkanna species by reversed phase high performance liquid chromatography. Planta Med. 73(3), 267-72, 2007

3.       KORKMAZ C.G., KORKMAZ K.S., KURYS P., ELBI C., KLOKK T.I., HAMMARSTROM C., SVINDLAND A., HAGER G.L., AND SAATCIOGLU F. Molecular cloning and characterization of STAMP2, an androgen regulated six-trans-membrane protein that is overexpressed in a subset of prostate cancers. Oncogene Jul 21;24(31):4934-45, 2005

4.       HAYAKAWA J., MITTAL S., WANG Y., KORKMAZ K.S., ADAMSON E., ENGLISH C., OMICHI M.,  McCLELLAND M., MERCOLA D. Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation by genotoxic stress. Mol. Cell.,  16 (Nov 19): 1-20, 2004

5.       KORKMAZ C.G., KORKMAZ K.S., MANOLA J., XI Z., RISBERG B., DANIELSEN H., KUNG J., SELLERS W.R., LODA M., SAATCIOGLU F. Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis. J Urol., 172(3):1134-9, 2004

6.       XI Z., KLOKK T. I., KORKMAZ K.S., KURYS P., ELBI C., RISBERG B., DANIELSEN H., LODA M., SAATCIOGLU F. Kallikrein 4 Is A Nuclear Protein That Is Over-Expressed In Prostate Cancer. Cancer Res., 64(7):2365-70, 2004

7.       ADAMSON E., DE BELL I., MITTAL S., WANG Y., HAYAKAWA J., KORKMAZ K., OHAGAN D., MCCLELLAND M., MERCOLA D. Egr1 signaling in prostate cancer. Cancer Biology & Therapy, 2(6):617-622, 2004

8.       SKOTHEIM, R.I., KORKMAZ, K.S. KLOKK, T. I., ABELER, V. M., KORKMAZ, C. G., NESLAND, J. M., FOSSA, S. D., LOTHE, R. A., SAATCIOGLU, F. NKX3.1 Expression Is Lost in Testicular Germ Cell Tumors. Am J Pathol., 163: 2149-2154, 2003

9.       KORKMAZ K.S., ELBI C. C., KORKMAZ C. G., LODA M., HAGER G.L., SAATCIOGLU F. Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer. JBC., 277(39): 36689-36696, 2002