Multiple Chemical Sensitivity is an acquired chronic condition with symptoms that recur reproducibly in response to low levels of exposure to multiple unrelated chemicals affecting multiple organs. Symptoms improve or resolve when incitants are removed. MCS may occur after single, high-dose exposures (i.e. chemical spills) or repeated low-level exposures to chemicals. Chemicals may be inhaled, ingested, absorbed by the skin or implanted (i.e. breast implants). A patient with MCS may not be able to eliminate chemicals in his or her body because the chemicals enter the body more rapidly than the body is able to eliminate them. The chemicals may then be stored in the heart, liver, and brain.
The symptoms of M.C.S. include, but are not limited to, the following: fatigue, headache, trouble breathing, muscle pain and joint pain, dizziness, irregular heartbeat, seizures, cognitive dysfunction including confusion, lack of memory, and lack of concentration. M.C.S. is similar to an allergy in that patients who are affected react to substances that are not harmful to others, but the biological mechanisms are dissimilar. Those with M.C.S. may appear healthy even when they are very ill.
Breast Implants and M.C.S.
The shell of a breast implant has the following composition:
1. 80% high molecular weight silicones 2. 20% finely powdered silica 3. catalyst: small amounts (50-100 parts per million) of a tin or platinum 4. impurities: -small amounts of (1-500 parts per million) of various smaller silicones -trace amounts of (<5 parts per million) of volatile (readily evaporating) materials like xylene and other organic compounds (impurities) -trace amounts (<5 parts per million) of metals (impurities).
The elastomer shell contains the component silica. Silica is a potent stimulant of nitric oxide synthesis and may act to stimulate the NO/ONOO- cycle in multiple chemical sensitivity. *
A specific sensitivity to the silicone elastomer is more likely to be a true allergy.
*Silica as a supplement compared to silica in a breast implant: Silica has very limited solubility in water, so that silica as a supplement will lead to very limited absorption into the body and any undissolved silica will be rapidly passed through the GI tract. That is very different from the amount of silica in breast implants, or the amount of silica in the lungs in cases of silicosis, where the silica is present in the body for months or years and can continuously irritate acting, in part at least, through nitric oxide.
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