Territorial behaviour is very common, particularly in unneutered females. Its characterised by growling, biting and lunging at your hands when you put them in to your rabbits space. The hutch and food bowl may be guarded viciously. Generally once in a neuteral environment away from their territory, such as being taken to play inside, the aggression disappears or much improves. The solution to this problem is neutering which helps in most cases although there may be a delay of several weeks after neutering, whilst the hormones reduce, for improvements to show. In the mean time you can by pass the problem by not putting your hands in the hutch, use a carry case instead.
If the agression is fear related then before you progress to picking up your rabbit you first have to gain its confidence. First it has to learn that you being around doesn't consitute a threat. Give it an old t-shirt you have worn to get it used to your smell. Then spend time sitting in your rabbits space, ignore it and make no sudden movements eventually it will learn that you aren't going to attack it when it comes close. Hand feed favourite foods and once it start coming to you start gently stroking it. Only once it is happy to be stroked and used to your presense can you move on to advanced things like picking it up.