I checked out Terence Dickenson's book NightWatch recently, which shows how to measure distances on the celestial sphere by holding your hand out at arm's length [Image1, How to Estimate Angles in the Sky, Angles in the Sky, Measuring Angular Distances, Wiki/Sextant]. Then the distances between your fingers and the two sides of your hand become angular measurements for the distances along rays between stars. Here the cloud cover ghost with his chin in Wichita is showing me the 20 to 25 degree angle associated with a posture of the hand held at arm's length that corresponds to the distance between Alkaid and Duhbe, one of the larger angles inside the Big Dipper, Ursa Major. This seems to be a typical "I see you, do you see me?" signal from my Watcher the Almighty, who is tracking me with a pleasant haunting. Here the little finger of the cloud cover ghost is fixed on "Ouray", Colorado, while the thumb seems to be at "Hugoton", Kansas. Like the previous satellite vision, this one seems to be a mind-mirror communication about the "hand of God". This is a good time of year to be observing the constellations, which I have charted in Orion Sky. The Vernal Equinox (in Aries 3000 years ago, and also called "The First Point of Aries") goes overhead through the meridian at about 11:00 PM now. This happens at midnight on September 22, the usual date of the Vernal Equinox. Now we have the "Age of Aquarius" because the "First Point of Aries" today passes through Pices on down through Aquarius. This has taken place because of the precession of the equinoxes, which takes approximately 26,000 years. During the Kingdom of David 3000 years ago, the ray from the pole passing through Aries went through the Meridian at midnight. I note Aries resembles both a horn and the highlight on the stocking of Andromeda, whose smile in Perseus-Pleiades-Aries becomes her bottom as Orion rises and stands erect. See the connection between the precession of the equinoxes and the Ice Ages.

I computed rejuvenation times for treatment with astragalosides and put them in a table, which I put on-line. The cloud cover seems to have responded by showing this as a "tip", or wing-tip left by a little bird, as in "a little bird told me".

Rejuvenation Times to Model Age 25 from Initial Age (Years) with Costs

Initial Actual Chronological Age	100	90	80	70	60	50	40	30
Rejuvenation time in years, 8 yrs/yr rate	9.375	8.125	6.875	5.685	4.375	3.125	1.875	0.625
Rejuvenation time in years, 9 yrs/yr rate	8.333	7.222	6.111	5.000	3.888	2.777	1.666	0.556
Rejuvenation time in years, Outer Limit	< 9.5	< 8.5	< 7.0	< 6.0	< 4.5	< 3.5	< 2	< 1
Actual Age at Final Model Age 25	< 109.5	< 98.5	< 87	< 76	< 64.5	< 53.5	< 42	< 31
Cost at $25.50 per month (dollars)	< 2907	< 2601	< 2142	< 1836	< 1377	< 1071	< 612	< 306

Rejuvenation Times from 60 to Final Model Ages t in Years with Cost in Dollars

Final Model Age t	55	50	45	40	35	30	25	20
Δt8 Rejuvenation time, B = 8 yrs/yr	0.625	1.25	1.875	2.5	3.125	3.75	4.375	5
Δt9 Rejuvenation time, B = 9 yrs/yr	0.556	1.111	1.667	2.222	2.778	3.333	3.889	4.444
Actual Age at Final Model Age t	< 60.63	< 61.26	< 61.88	< 62.51	< 63.13	< 63.76	< 64.38	< 65.1
= t0 + Δt	> 60.55	> 61.11	> 61.66	> 62.22	> 62.77	> 63.33	> 63.88	> 64.4
Cost at $25.50 per month (dollars)	< 191.25	< 382.5	< 573.8	< 765.1	< 956.3	< 1148	< 1339	< 1531
= $25.50(12)Δt	> 170.12	> 339.97	> 510.1	> 679.9	> 850.07	> 1019	> 1190	> 1359

These times look very optimistic, but the process actually seems to be glacial, something like aging itself. It is usually 9 months before any detectable change can be observed, unless one is measuring telomere lengths by a very accurate method. In some cases, measurement resolution is only about 200 base pairs, while we observe 460 base pairs of telomere growth per year using TA-65 half of the year, yielding about 9 years per year rejuvention rate. Eight years per year rejuvenation rates have also been observed with TA-65 with respect to telomere reconstruction. Closing the telomere t-loops as the telomeres get longer eliminates senescent cells, which change their pattern of gene expression back to that of the immmortal phenotype. We still need more measurements of telomere growth done with off-the-shelf astragalus extracts. Prior experience with ethanol and water astragalus extracts such as TA-41 suggests results comparable to TA-65 results may be obtained. In the past, long-term use of astragalus extracts was rare, because the medicine is expensive and is usually applied to counteract a specific problem, such as lymphoma night-sweats, or cold prevention in the winter. Geron published their result [Geron Patent] that astragalus extract activates telomerase in 2005, and TA Sciences announced that their product TA-65 was based on an astragalus-derived chemical in the Spring of 2007. I started my own experiment with GAIA Herbs astragalus extract in May 2007. By then it was understood from work done with hTERT plasmids and other techniques that telomerase activation can make cells young again, eliminating their senescent cell properties by lengthening the shrinking telomeres in mitotic cells until the telomere t-loops close, eliminating a DNA damage signal for open-ended DNA that causes transition to the senescent state. When telomere t-loops get too short and cause the DNA damage signal triggering cellular senescence, cells like dermal fibroblasts change grotesquely, swelling up to several times their former size and becoming sources of matrix metalloproteinases collagenase, stromelysin, and other factors that attack the extracellular matrix, causing wrinkled skin and other objectionable aging problems. Senescent fibroblasts also show reduced expression of TIMP1 and TIMP3, tissue inhibitors of matrix metalloproteinases. In addition to managing telomerase activation in an antiaging program, we also improve our antioxidant margins against DNA damage and take steps to protect mitochondria and cell membranes as part of our total program. See my file longevity.

Perhaps the image of HandShake Man (Wikipedia Man?) with his eyes in Canada and mouth in Montana, showing one hand cut off but handing it to Kansas, signifies that coworkers in my field of research have a hard time meeting me and shaking hands. After all, I tend to hang out in research libraries, hovering over glowing computer screens. I can make grand claims for my rejuvenation scheme above, but can I get hearty handshake congratulations for it from other students of the discipline, like I once recieved a handshake from Werner Heisenberg?