Eduardo Candelario-Jalil

Neuroscience Research

Scientific Publications

Published or in Press

Sood RR, Taheri S, Candelario-Jalil E, Estrada EY, Rosenberg GA. Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain. Journal of Cerebral Blood Flow and Metabolism 2008; 28(2): 431-438. PDF

Candelario-Jalil E, Taheri S, Yang Y, Sood R, Grossetete M, Estrada EY, Fiebich BL, Rosenberg GA. Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat. Journal of Pharmacology and Experimental Therapeutics 2007; 323(2): 488-498. PDF

Candelario-Jalil E, de Oliveira AC, Graf S, Bhatia HS, Hull M, Munoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. Journal of Neuroinflammation 2007; 4(1):25. PDF

Candelario-Jalil E, González-Falcón A, García-Cabrera M, León OS, Fiebich BL. Post-ischemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischemia in rats. Journal of Neurochemistry 2007; 100(4): 1108-1120. PDF

Candelario-Jalil E. Cyclooxygenase-2 regulation of brain lipid composition. Future Lipidology 2007 Aug; 2(4): 399-402. PDF

Candelario-Jalil E, Akundi RS, Bhatia HS, Lieb K, Appel K, Muñoz E, Hull M, Fiebich BL. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. Journal of Neuroimmunology 2006; 174(1-2): 39-51. PDF

Waschbisch A, Fiebich BL, Akundi RS, Schmitz ML, Hoozemans JJ, Candelario-Jalil E, Virtainen N, Veerhuis R, Slawik H, Yrjanheikki J, Hull M. Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. Journal of Neurochemistry 2006; 96(3): 680-693. PDF

Fiebich BL, Candelario-Jalil E (co-first author), Mantovani M, Heinzmann M, Akundi RS, Hull M, Knorle R, Schnierle P, Finkenzeller G, Aicher B. Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. Pharmacological Research 2006; 53(4): 391-396. PDF

Candelario-Jalil E, Slawik H, Ridelis I, Waschbisch A, Akundi RS, Hüll M, Fiebich BL. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum. Journal of Molecular Neuroscience 2005; 27(3): 303-10. PDF

Martínez-Sánchez G, Al-Dalain SM, Menéndez S, Re L, Giuliani A, Candelario-Jalil E, Alvarez H, Fernández-Montequin JI, León OS. Therapeutic efficacy of ozone in patients with diabetic foot. European Journal of Pharmacology 2005; 523(1-3): 151-161. PDF

de la Vega L, Muñoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gescheidmeir H, Färber L, Mueller W, Stratz T, Fiebich BL. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochemical Pharmacology 2005; 70(3): 369-380. PDF

Candelario-Jalil E, Mhadu NH, González-Falcón A, García-Cabrera M, Muñoz E, León S, Fiebich BL. Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. Journal of Neuroinflammation 2005; 2(1):3. PDF http://www.jneuroinflammation.com/content/2/1/3

Akundi RS, Candelario-Jalil E, Hess S, Hüll M, Lieb K, Gebicke-Haerter PJ, Fiebich BL. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia 2005 51(3):199-208. PDF http://www3.interscience.wiley.com/cgi-bin/abstract/110434693/ABSTRACT

Lieb K, Biersack L, Waschbisch A, Orlikowski S, Akundi RS, Candelario-Jalil E, Hüll M, Fiebich BL. Serotonin via 5-HT7 receptors activates p38 MAP kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. Journal of Neurochemistry 2005; 93 (3): 549-559. PDF

Candelario-Jalil E, González-Falcón A, García-Cabrera M, León OS, Fiebich BL. Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. Brain Research 2004; 1007 (1-2): 98-108. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15064140

Ajamieh HH, Menéndez S, Martínez-Sánchez G, Candelario-Jalil E, Re L, Giuliani A, León OS. Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver International 2004; 24 (1): 55-62. PDF http://www.blackwell-synergy.com/links/doi/10.1111/j.1478-3231.2004.00885.x/abs

Fiebich BL, Akundi RS, Seidel M, Geyer V, Haus U, Müller W, Stratz T, Candelario-Jalil E. Expression of 5-HT3A receptors in cells of the immune system. Scandinavian Journal of Rheumatology 2004; 33: 9-11. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15515405

Fiebich BL, Akundi RS, Lieb K, Candelario-Jalil E, Gmeiner D, Haus U, Müller W, Stratz T, Munoz E. Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide-stimulated primary human monocytes. Scandinavian Journal of Rheumatology 2004; 33: 28-32. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15515409

Seidel MF, Ulrich-Merzenich G, Fiebich BL, Candelario-Jalil E, Koch FW, Vetter H. Tropisetron inhibits serotonin-induced PGE2 release from macrophage-like synovial cells in serum-free tissue culture. Scandinavian Journal of Rheumatology 2004; 33: 33. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15515410

Candelario-Jalil E, González-Falcón A, García-Cabrera M, Álvarez D, Al-Dalain S, Martínez G, León OS, Springer JE. Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. Journal of Neurochemistry 2003; 86 (3): 545-555. PDF http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2003.01812.x/abs

Candelario-Jalil E, Alvarez D, Merino N, León OS. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neuroscience Research 2003; 47 (2): 245-253. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14512150

Candelario-Jalil E, León OS. Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates. BMC Pharmacology 2003; 3 (1): 7. PDF http://www.biomedcentral.com/1471-2210/3/7

González-Falcón A; Candelario-Jalil E (co-first author), García-Cabrera M, León OS. Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats. Brain Research 2003; 990 (1-2): 1-7. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14568323

Candelario-Jalil E, Álvarez D, García-Cabrera M, González-Falcón A, Martínez G, Merino N, Giuliani A, León OS. Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia. European Journal of Pharmacology 2002; Vol 453 (2-3): 189-195. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12398903

Candelario-Jalil E, Alvarez D, Castañeda JM, Al-Dalain SM, Martínez G, Merino N, León OS. The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. Brain Research 2002; 927 (2): 212-5. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11821016

Ajamieh H, Merino N, Candelario-Jalil E, Menéndez S, Martínez-Sánchez G, Re L, Giuliani A, León OS. Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacological Research 2002; 45 (4): 333-339. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12030798

Candelario-Jalil E, Mhadu NH, Al-Dalain SM, Martínez G, León OS. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neuroscience Research 2001; 41 (3): 233-241. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11672836

Candelario-Jalil E, Al-Dalain SM, Castillo R, Martínez G, León OS. Selective vulnerability to kainate-induced oxidative damage in different rat brain regions. Journal of Applied Toxicology 2001; 21 (5): 403-407. PDF http://www3.interscience.wiley.com/cgi-bin/abstract/85513230/ABSTRACT

Martínez G, Candelario-Jalil E, Giuliani A, León OS, Sam S, Delgado R, Núñez Sellés AJ. Mangifera indica L. extract (QF808) reduces ischaemia-induced neuronal loss and oxidative damage in the gerbil brain. Free Radical Research 2001;35 (5): 465-73. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11767405

Candelario-Jalil E, Al-Dalain SM, León OS, Menéndez S, Pérez-Davison G, Merino N, Sam S, Ajamieh HH. Oxidative preconditioning affords protection against carbon tetrachloride-induced glycogen depletion and oxidative stress in rats. Journal of Applied Toxicology 2001; 21 (4): 297-301. PDF http://www3.interscience.wiley.com/cgi-bin/abstract/85006830/ABSTRACT

Al-Dalain SM, Martínez G, Candelario-Jalil E, Menéndez S, Re L, Giuliani A,León OS. Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats. Pharmacological Research 2001; 44 (5): 391-6. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11712870

Candelario-Jalil E, Ajamieh HH, Sam S, Martínez G, León OS. Nimesulide limits kainate-induced oxidative damage in the rat hippocampus. European Journal of Pharmacology 2000; 390 (3): 295-298. PDF http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10708736

Peralta C, León OS, Xaus C, Prats N, Candelario-Jalil E, Planell ES, Puig-Parellada P, Gelpí E, Roselló-Catafau J. Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: antioxidant-prooxidant balance. Free Radical Research 1999; 31 (3): 191-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10499775