| Pick # | Team | Player |
| 1 | Dolphins | Chris Long, DE/LB, Virginia |
| 2 | Rams | Sedrick Ellis, DT, USC |
| 3 | Falcons | Vernon Gholston, LB/DE, OSU |
| 4 | Raiders | Jake Long, T, Michigan |
| 5 | Chiefs
| Glenn Dorsey, DT, LSU |
| 6 | Jets | Leodis McKelvin, CB, Troy |
| 7 | Patriots (from 49ers) | Darren McFadden, RB, Arkansas |
| 8 | Ravens | Dominique Rodgers-Cromartie, CB, Tennessee State |
| 9 | Bengals | Phillip Merling, DE, Clemson |
| 10 | Saints | Keith Rivers, LB, USC |
| 11 | Bills | Ryan Clady, T, Boise State |
| 12 | Broncos | Rashard Mendenhall, RB, Illinois |
| 13 | Panthers | Malcolm Kelly, WR, Oklahoma |
| 14 | Bears | Matt Ryan, QB, Boston College |
| 15 | Lions | Jonathan Stewart, RB, Oregon |
| 16 | Cardinals | Chris Williams, T, Vanderbilt |
| 17 | Vikings | Derrick Harvey, LB/DE, Vikings |
| 18 | Texans | Sam Baker, T, USC |
| 19 | Eagles | DeSean Jackson, WR, California |
| 20 | Buccaneers | Antoine Cason, CB, Arizona |
| 21 | Redskins | Early Doucet, WR, LSU |
| 22 | Cowboys (from Browns) | Josh Barrett, SS, Arizona State |
| 23 | Steelers | Kenny Phillips, FS, Miami |
| 24 | Titans | Limas Sweed, WR, Texas |
| 25 | Seahawks | Branden Albert, G, Virginia |
| 26 | Jaguars | James Hardy, WR, Indiana |
| 27 | Chargers | Jeff Otah, T, PITT |
| 28 | Cowboys | Devin Thomas, WR, Michigan State |
| 29 | 49ers (from Colts) | Mike Jenkins, CB, South Florida |
| 30 | Packers | Fred Davis, TE, USC |
| 31 | Patriots | Forfeit |
| 32 | Giants | Quentin Groves, LB/DE, Auburn |
2nd RD
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| 1 | Dolphins | Brandon Flowers, CB, Virginia Tech |
| 2 | Rams | Dan Connor, LB, Penn State |
| 3 | Falcons | Brian Brohm, QB, Louisville |
| 4 | Raiders | Pat Sims, DT, Auburn |
| 5 | Cheifs | Reggie Smith, CB/FS, Oklahoma |
| 6 | Jets | Kentwan Balmer, DE, North Carolina |
| 7 | 49ers | Carl Nicks, T, Nebraska |
| 8 | Ravens | Andre Woodson, QB, Kentucky |
| 9 | Bengals | Xavier Adibi, LB, Virginia Tech |
| 10 | Saints | Dre Moore, DT, Maryland |
| 11 | Bills | Lawrence Jackson, DE, USC |
| 12 | Broncos | Marcus Howard, LB, Georgia |
| 13 | Panthers | Trevor Laws, DT, Notre Dame |
| 14 | Bears | Felix Jones, RB, Arkansas |
| 15 | Lions | Aqib Talib, CB, Kansas |
| 16 | Cardinals | Tracy Porter, CB, Indiana |
| 17 | Vikings | Martellus Bennett, TE, Texas A&M |
| 18 | Falcons(Texans) | Heath Benedict, T, Newberry |
| 19 | Eagles | Erin Hederson, LB, Maryland |
| 20 | Buccaneers | Red Bryant, DT, Texas A&M |
| 21 | Redskins | Calais Campbell, DE, Miami |
| 22 | Packers(Browns) | Jarod Meyo, LB, Tennessee |
| 23 | Steelers | Patrick Lee, CB, Auburn |
| 24 | Titans | Terrell Thomas, CB, USC |
| 25 | Seahawks | Brian Cottam, TE, Tennessee |
| 26 | Jaguars | Marcus Harrison, DT, Arkansas |
| 27 | Dolphins(Chargers) | Curtis Lofton, LB, Oklahoma |
| 28 | Cowboys | Tavares Gooden, LB, Miami |
| 29 | Colts | Phillip Wheeler, LB, Georgia Tech |
| 30 | Packers | Jamar Adams, SS, Michigan |
| 31 | Patriots | Charles Godfrey, CB, Iowa |
| 32 | Giants | Tom Zbwikowski, SS, Notre Dame |