| Pick # | Team | Player |
| 1 | Dolphins | James Laurinaitis, LB, Ohio State |
| 2 | Rams | Tim Tebow, QB, Florida* |
| 3 | Falcons | Michael Crabtree, WR, Texas Tech* |
| 4 | Raiders | Chris Wells, RB, Ohio State* |
| 5 | Cheifs | Michael Oher, T, Mississippi |
| 6 | Jets | Percy Harvin, WR, Florida* |
| 7 | 49ers | Malcolm Jenkins, CB, Ohio State |
| 8 | Ravens | Vontae Davis, CB, Illinois* |
| 9 | Bengals | Tyson Jackson, DE, LSU |
| 10 | Saints | Darrius Heyward-Bay, WR, Maryland* |
| 11 | Bills | Sen'Derrick Marks, DT, Auburn* |
| 12 | Broncos | Keiland Williams, RB, LSU* |
| 13 | Panthers | Hunter Cantwell, QB, Louisville |
| 14 | Bears | Fili Maola, DT, USC |
| 15 | Lions | George Selvie, OLB, South Florida* |
| 16 | Cardinals | Rey Maualuga, LB, USC |
| 17 | Vikings | Taylor Mays, SS, USC* |
| 18 | Texans | Knowshon Moreno, RB, Geogia* |
| 19 | Eagles | Myron Rolle, SS, Florida State* |
| 20 | Buccaneers | Brandon LaFell, WR, LSU* |
| 21 | Redskins | Cam Chanceller, SS, Virginia Tech* |
| 22 | Browns | Sean Lee, LB, Penn State |
| 23 | Steelers | Darry Beckwith, LB, LSU |
| 24 | Titans | Mike Mickens, CB, Cincinnati |
| 25 | Seahawks | Andrew Quarless, TE, Penn State |
| 26 | Jaguars | Oderick Turner, WR, PITT* |
| 27 | Chargers | Jeremy Maclin, WR, Missouri* |
| 28 | Cowboys | Nic Harris, SS, Oklahoma |
| 29 | Colts | Brandon Spikes, LB, Florida* |
| 30 | Packers | Andre Smith, T, Alabama* |
| 31 | Patriots | Brian Cushing, LB, USC |
| 32 | Giants | C.J Spiller, RB, Clemson* |
| 2nd RD | ||
| Pick # | Team | Player |
| 1 | Dolphins | William Moore, FS, Missouri |
| 2 | Rams | Jaison Williams, WR, Oregon |
| 3 | Falcons | Javarris James, RB, Miami* |
| 4 | Raiders | Demarcus Granger, DT, Oklahoma* |
| 5 | Cheifs | Michael Johnson, DE/OLB, Georgia Tech |
| 6 | Jets | Chris Clemons, FS, Clemson |
| 7 | 49ers | Max Unger, T, Oregon |
| 8 | Ravens | Reggie Carter, LB, UCLA* |
| 9 | Bengals | Phil Loadholt, T, Oklahoma |
| 10 | Saints | Chase Coffman, TE, Missouri |
| 11 | Bills | Pat White, QB/WR/RB, West Virginia |
| 12 | Broncos | Wopamo Osaisai, CB, Stanford |
| 13 | Panthers | James Davis, RB, Clemson |
| 14 | Bears | Matt Stafford, QB, Georgia* |
| 15 | Lions | Duke Robinson, G, Oklahoma |
| 16 | Cardinals | Derek Pegues, FS, Missippi State |
| 17 | Vikings | Todd Boekman, QB, Ohio State |
| 18 | Texans | Ciron Black, T, LSU* |
| 19 | Eagles | Anthony Heygood, LB, Purdue |
| 20 | Buccaneers | Ryan Purvis, TE, Boston College |
| 21 | Redskins | Lawrence Wilson, DE, Ohio State |
| 22 | Browns | Tavard Lindley, CB, Kentucky* |
| 23 | Steelers | Scott Mckillop, LB, Pittsburgh |
| 24 | Titans | Patrick Chung, SS, Oregon |
| 25 | Seahawks | Brian Robiskie, WR, Ohio State |
| 26 | Jaguars | Kevin Ellison, SS, USC |
| 27 | Chargers | Demonte Bolden, DT, Tennessee |
| 28 | Cowboys | Patrick Turner, WR, USC |
| 29 | Colts | Marcus Freeman, LB, Ohio State |
| 30 | Packers | Derrick Williams, WR, Penn State |
| 31 | Patriots | Michael Hamlin, SS, Clemson |
| 32 | Giants | Jasper Brinkley, LB, South Carolina |